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According to research on tobacco composition, cured tobacco lines can contain between 0.2 and 4.75% nicotine by weight, depending on plant genetics, growing conditions, degree of ripening, fertilizer treatment, and position of the leaf on the stalk

To do this, they took urine samples from smokers of both factory-made and roll-your-own cigarettes, and measured the levels of particular molecules that are made when our bodies break these tobacco chemicals down

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